Invitrogen™ NFX1 Polyclonal Antibody

Catalog No.	Quantity
PIPA567299	100 μL

Catalog No. PIPA567299 Supplier Invitrogen™ Supplier No. PA567299

Description

Rabbit Polyclonal Antibody

Immunogen sequence: SSPPPCHLSRQ VPYDEISAVH QHSYHPSGSK PKSQQTSFQS SPCNKSPKSH GLQNQPWQKL RNEKHHIRVK KAQSLAEQTS DTA Highest antigen sequence identity to the following orthologs - mouse 74%, rat 74%.

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

Specifications

• Antigen: NFX1
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.6 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: NFX1
• Gene Accession No.: Q12986
• Gene Alias: 1300017N15Rik; 3000003M19Rik; DKFZp779G2416; MGC20369; m-Nfx.1; NFX.1; Nfx1; NFX2; nuclear transcription factor, X box-binding protein 1; nuclear transcription factor, X-box binding 1; TEG-42; testis expressed gene 42; Tex42; transcriptional repressor NF-X1; X-box binding 1
• Gene Symbols: NFX1
• Host Species: Rabbit
• Immunogen: Recombinant Human NFX1. Recombinant protein control fragment (Product #RP-107937).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4799
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG