Invitrogen™ NGEF Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552521

Catalog No. PIPA552521

Description

Immunogen sequence: METRESEDLE KTRRKSASDQ WNTDNEPAKV KPELLPEKEE TSQADQDIQD KEPHCHIPIK RNSIFNRSIR RKSKAKARDN PERNASCLAD SQDNGKSVNE PLTLNIPWSR TPPCRTAMQT DPGAQEMSES SST Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 26%.

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.

Specifications

• Antigen: NGEF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NGEF
• Gene Alias: ARHGEF27; Besh3; brain-enriched SH3-domain protein Besh3; ephexin; ephexin-1; eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; Ngef; Tims2; transforming immortalised mammary epithelial sequence 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25791
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N5V2
• Gene Symbols: NGEF
• Immunogen: Recombinant protein corresponding to Human NGEF. Recombinant protein control fragment (Product #RP-89831).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov