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Tocris Bioscience™ NH 125
GREENER_CHOICE

Catalog No. 343950
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Quantity:
10 mg
50 mg
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CaM kinase III (eEF-2 kinase) inhibitor

Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 μM) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC50 = 6.6 μM) and in vivo.

Chemical Identifiers

CAS 278603-08-0
Molecular Formula C27H45IN2

Specifications

Quantity 50 mg
Formula Weight 524.56
Purity >98%
Molecular Weight (g/mol) 524.575
Chemical Name or Material NH 125
Recommended Storage Desiccate at -20°C
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