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Invitrogen™ Nhe-1 Polyclonal Antibody
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Catalog No. PIPA561764
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100 μL
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PIPA561764 100 μL
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Catalog No. PIPA561764 Supplier Invitrogen™ Supplier No. PA561764
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KILRNNLQKT RQRLRSYNRH TLVADPYEEA WNQMLLRRQK ARQLEQKINN YLTVPAHKLD SPTMSRARIG SDPLAYEPKE DLPVITIDPA Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.

The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nhe-1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SLC9A1
Gene Accession No. P19634
Gene Alias Apnh; APNH1; AW554487; LIKNS; Mir5122; mir-5122; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; Na-Li countertransporter; Nhe1; NHE-1; PPP1R143; protein phosphatase 1, regulatory subunit 143; SLC9A1; slow-wave epilepsy; sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1; solute carrier family 9 member A1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; swe
Gene Symbols SLC9A1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Nhe-1. Recombinant protein control fragment (Product #RP-103029).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6548
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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