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Invitrogen™ Nicastrin Polyclonal Antibody
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Catalog No. PIPA589872
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100 μL
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PIPA589872 100 μL
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Catalog No. PIPA589872 Supplier Invitrogen™ Supplier No. PA589872
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RFLRARNISG VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL E; Positive Samples: Mouse brain, Rat brain, Rat spleen; Cellular Location: Melanosome, Membrane, Single-pass type I membrane protein.

NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nicastrin
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.07 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene NCSTN
Gene Accession No. P57716, Q8CGU6, Q92542
Gene Alias 9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317
Gene Symbols NCSTN
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 429-669 of human NCSTN (NP_0561461).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23385, 289231, 59287
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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