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Invitrogen™ NIK Polyclonal Antibody
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Catalog No. 01675657
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100 μg
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Catalog No. Quantity
01-675-657 100 μg
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Catalog No. 01-675-657 Supplier Invitrogen™ Supplier No. PA141320
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Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for MAP3K14 (transient overexpression lysate).

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
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Specifications

Antigen NIK
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene MAP3K14
Gene Accession No. Q99558
Gene Alias aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
Gene Symbols MAP3K14
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 687-703 of human NIK.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9020
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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