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Invitrogen™ NIK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100732

Catalog No. PIPA5100732


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Description

Description

Antibody detects endogenous levels of total NIK.

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NIK
Polyclonal
Unconjugated
MAP3K14
aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
Rabbit
Affinity chromatography
RUO
53859, 9020
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q99558, Q9WUL6
MAP3K14
A synthesized peptide derived from human MAP3K14(Accession Q99558), corresponding to amino acid residues S787-A837.
100 μL
Primary
Human, Mouse
Antibody
IgG
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