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Invitrogen™ NIK Polyclonal Antibody
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Catalog No. PIPA588155
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100 μL
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PIPA588155 100 μL
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Catalog No. PIPA588155 Supplier Invitrogen™ Supplier No. PA588155
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KFSVEEYLVH ALQGSVSSGQ AHSLTSLAKT WAARGSRSRE PSPKTEDNEG VLLTEKLKPV DYEYREEVHW ATHQLRLGRG SFGEVHRMED KQTGFQCAVK KVRLEVFRAE ELMACAGLTS PRIVPLYGAV REGPWVNIFM ELLEGGSLGQ LVKEQGCLPE DRALYYLGQA LEGLEYLHSR RILHGDVKAD NVLLSSDGSH AALCDFGHAV CLQPDGLGKS LLTGDYIPGT ETHMAPEVVL GRSCDAKVDV WSSCCMMLHM LNGCHPWTQF FRGPLCLKIA SEPPPVREIP PSCAPLTAQA IQEGLRKEPI HRVSAAELGG KVNRALQQVG GLK Positive Samples: Raji; Cellular Location: Cytoplasm.

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NIK
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene MAP3K14
Gene Accession No. Q99558
Gene Alias aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
Gene Symbols MAP3K14
Host Species Rabbit
Immunogen Recombinant Protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 360640
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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