Invitrogen™ NIK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110932

Catalog No. PIPA5110932

Description

Immunogen sequence: SVYKLEAVEK SPVFCGKWEI LNDVITKGTA KEGSEAGPAA ISIIAQAECE NSQEFSPTFS ERIFIAGSKQ YSQSESLDQI PNNVAHA.

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Specifications

• Antigen: NIK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K14
• Gene Alias: aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9020
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q99558
• Gene Symbols: MAP3K14
• Immunogen: Recombinant Protein corresonding to Human NIK. Recombinant protein control fragment (Product #RP-108163).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG