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Tocris Bioscience™ Nimbolide
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Catalog No. 728925
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25 mg
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72-892-5 25 mg
72-895 5 mg
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Catalog No. 72-892-5 Supplier Tocris Bioscience™ Supplier No. 7289/25
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Description

RNF114 inhibitor

Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. This compound impairs proliferation of triple-negative breast cancer cell lines. Nimbolide also induces apoptotic cell death in a Waldenströms macroglobulinemia cell line (BCWM1) and inhibits tumor growth in a xenograft model of Waldenströms macroglobulinemia.

Nimbolide can be used for the development of Degraders that utilize RNF114 as an E3 ligase for Targeted Protein Degradation.

Specifications

Chemical Name or Material (2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
CAS 25990-37-8
Quantity 25 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C27H30O7
Purity 0.97
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