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Invitrogen™ NISCH Polyclonal Antibody
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Catalog No. PIPA554718
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PIPA554718 100 μL
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Catalog No. PIPA554718 Supplier Invitrogen™ Supplier No. PA554718
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AHFLHFHFYE INGITAALAE ELFEKGEQLL GAGEVFAIGP LQLYAVTEQL QQGKPTCASG DAKTDLGHIL DFTCRLKYLK VSGTEGPFGT SNIQEQLLPF DLSIFKSLHQ VEISHCDAKH IRGLVASKPT LATLSVRFSA TSMKEV Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 93%.

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NISCH
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NISCH
Gene Accession No. Q9Y2I1
Gene Alias 1200007D05Rik; 3202002H23Rik; AW494485; hIRAS; I-1; I-1 receptor candidate protein; I1R; I1R candidate protein; imidazoline receptor 1; imidazoline receptor antisera selected; Imidazoline receptor antisera-selected protein; imidazoline receptor I-1; imidazoline receptor I-1-like protein; Imidazoline-1 receptor; Imidazoline-1 receptor candidate protein; IR1; IRAS; KIAA0975; NISCH; Nischarin
Gene Symbols NISCH
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NISCH. Recombinant protein control fragment (Product #RP-91062).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11188
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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