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Invitrogen™ Nitrotyrosine Monoclonal Antibody (HM.11), Biotin

Catalog No. FERMA549080
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50 μg
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Catalog No. Quantity
FERMA549080 50 μg
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Catalog No. FERMA549080 Supplier Invitrogen™ Supplier No. MA549080

Description

Mouse Monoclonal Antibody

The monoclonal antibody HM.11 recognizes nitrotyrosine, both with the free amino acid as well as with proteins containing nitrotyrosine.

Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from superoxide and nitric oxide (NO) radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e. g., alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and superoxide dismutase (SOD). Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious, and degenerative human diseases, such as Alzheimer's and Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. At the protein level, tyrosine nitration can lead to loss or alteration of protein function, as demonstrated for the oncogenic protein p53 and the mitochondrial protein, manganese-dependent superoxide dismutase (MnSOD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nitrotyrosine
Applications Inhibition Assays, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone HM.11
Concentration 100 μg/mL
Conjugate Biotin
Formulation PBS with 0.1% BSA and 0.02% sodium azide
Gene Alias Nitro-tyrosine
Host Species Mouse
Immunogen Nitrated KLH.
Purification Method Protein G
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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