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Invitrogen™ Nitrotyrosine Monoclonal Antibody (HM11)
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Catalog No. 321900
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100 μg
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Catalog No. Quantity
32-190-0 100 μg
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Catalog No. 32-190-0 Supplier Invitrogen™ Supplier No. 321900
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Description

Mouse Monoclonal Antibody

Nitrotyrosine Monoclonal Antibody for Western Blot, IHC

Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from superoxide and nitric oxide (NO) radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e. g., alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and superoxide dismutase (SOD). Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious, and degenerative human diseases, such as Alzheimer's and Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. At the protein level, tyrosine nitration can lead to loss or alteration of protein function, as demonstrated for the oncogenic protein p53 and the mitochondrial protein, manganese-dependent superoxide dismutase (MnSOD).
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Specifications

Antigen Nitrotyrosine
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone HM11
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Alias Nitro-tyrosine
Host Species Mouse
Immunogen Nitrotyrosine attached to a carrier protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
Target Molecule Chemical
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