Invitrogen™ NKCC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588206

Catalog No. PIPA588206

Description

Positive Samples: Mouse pancreas, Rat brain; Cellular Location: Membrane, Multi-pass membrane protein Immunogen sequence: GEASGESEPA KGSEEAKGRF RVNFVDPAAS SSAEDSLSDA AGVGVDGPNV SFQNGGDTVL SEGSSLHSGG GGGSGHHQHY YYDTHTNTYY LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLAELHDE LEKEPFEDGF ANGEESTPTR DAVVTYTAES K.

NKCC1 mediates sodium and chloride transport and reabsorption. NKCC1 is a membrane protein and is important in maintaining proper ionic balance and cell volume. NKCC1 is an electrically silent transporter system that mediates sodium and chloride reabsorption. Further, NKCC1 plays a vital role in the regulation of ionic balance and cell volume and is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for NKCC1. Diseases associated with SLC12A2 include Basosquamous Carcinoma and Metatypical Basal Cell Carcinoma.

Specifications

• Antigen: NKCC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC12A2
• Gene Alias: 9330166H04Rik; basolateral NaK(2Cl) cotransporter; basolateral Na-K-Cl symporter; BSC; BSC2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; little ears; lte; mBSC2; Na-K-2Cl- cotransporter; Na-K-Cl cotransporter; NKCC1; PPP1R141; protein phosphatase 1, regulatory subunit 141; Slc12a2; slc12a4; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; solute carrier family 12 (potassium/chloride transporters), member 2; solute carrier family 12 (potassium/chloride transporters), member 4; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12 member 2; solute carrier family 12, member 2; sy-ns; zfnkcc1; zgc:85961; zmp:0000000537
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20496, 6558, 83629
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.26 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P55011, P55012
• Gene Symbols: SLC12A2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human SLC12A2 (NP_0010371).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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