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Invitrogen™ NKCC1 Polyclonal Antibody
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Catalog No. PIPA588206
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100 μL
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PIPA588206 100 μL
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Catalog No. PIPA588206 Supplier Invitrogen™ Supplier No. PA588206
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse pancreas, Rat brain; Cellular Location: Membrane, Multi-pass membrane protein Immunogen sequence: GEASGESEPA KGSEEAKGRF RVNFVDPAAS SSAEDSLSDA AGVGVDGPNV SFQNGGDTVL SEGSSLHSGG GGGSGHHQHY YYDTHTNTYY LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLAELHDE LEKEPFEDGF ANGEESTPTR DAVVTYTAES K.

NKCC1 mediates sodium and chloride transport and reabsorption. NKCC1 is a membrane protein and is important in maintaining proper ionic balance and cell volume. NKCC1 is an electrically silent transporter system that mediates sodium and chloride reabsorption. Further, NKCC1 plays a vital role in the regulation of ionic balance and cell volume and is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for NKCC1. Diseases associated with SLC12A2 include Basosquamous Carcinoma and Metatypical Basal Cell Carcinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NKCC1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene SLC12A2
Gene Accession No. P55011, P55012
Gene Alias 9330166H04Rik; basolateral NaK(2Cl) cotransporter; basolateral Na-K-Cl symporter; BSC; BSC2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; little ears; lte; mBSC2; Na-K-2Cl- cotransporter; Na-K-Cl cotransporter; NKCC1; PPP1R141; protein phosphatase 1, regulatory subunit 141; Slc12a2; slc12a4; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; solute carrier family 12 (potassium/chloride transporters), member 2; solute carrier family 12 (potassium/chloride transporters), member 4; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12 member 2; solute carrier family 12, member 2; sy-ns; zfnkcc1; zgc:85961; zmp:0000000537
Gene Symbols SLC12A2
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20496, 6558, 83629
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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