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Invitrogen™ NKCC2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA541995
Description
Peptide sequence: NEKKSRGFFN YQASIFAENF GPRFTKGEGF FSVFAIFFPA ATGILAGANI Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%.
The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
Specifications
NKCC2 | |
Polyclonal | |
Unconjugated | |
SLC12A1 | |
AI788571; apical Na(2Cl)K cotransporter; BSC1; bumetanide-sensitive cotransporter type 1; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform A; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform B; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform F; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; D630042G03Rik; Kidney-specific Na-K-Cl symporter; mBSC1; MGC48843; Na-K-2Cl cotransporter; NKCC2; NKCC2A variant A; SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; solute carrier family 12 member 1; Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); solute carrier family 12, member 1; Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); urehr3 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
6557 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.5 mg/mL | |
PBS with 2% sucrose and 0.09% sodium azide | |
Q13621 | |
SLC12A1 | |
Synthetic peptide directed towards the N-terminal of human SLC12A1 (aa 351-400). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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