Invitrogen™ NKCC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA541995

Catalog No. PIPA541995

Description

Peptide sequence: NEKKSRGFFN YQASIFAENF GPRFTKGEGF FSVFAIFFPA ATGILAGANI Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%.

The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.

Specifications

• Antigen: NKCC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC12A1
• Gene Alias: AI788571; apical Na(2Cl)K cotransporter; BSC1; bumetanide-sensitive cotransporter type 1; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform A; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform B; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform F; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; D630042G03Rik; Kidney-specific Na-K-Cl symporter; mBSC1; MGC48843; Na-K-2Cl cotransporter; NKCC2; NKCC2A variant A; SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; solute carrier family 12 member 1; Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); solute carrier family 12, member 1; Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); urehr3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6557
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q13621
• Gene Symbols: SLC12A1
• Immunogen: Synthetic peptide directed towards the N-terminal of human SLC12A1 (aa 351-400).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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