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Invitrogen™ NKCC2 Polyclonal Antibody
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Catalog No. PIPA553726
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100 μL
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PIPA553726 100 μL
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Catalog No. PIPA553726 Supplier Invitrogen™ Supplier No. PA553726
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SQGFDISQVL QVQEELERLE QERLALEATI KDNECEEESG GIRGLFKKAG KLNITKTTPK KDGSINTSQS MHVGEFNQKL VEASTQFKKK QEKGTIDVWW LFDD Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.

The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NKCC2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SLC12A1
Gene Accession No. Q13621
Gene Alias AI788571; apical Na(2Cl)K cotransporter; BSC1; bumetanide-sensitive cotransporter type 1; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform A; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform B; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform F; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; D630042G03Rik; Kidney-specific Na-K-Cl symporter; mBSC1; MGC48843; Na-K-2Cl cotransporter; NKCC2; NKCC2A variant A; SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; solute carrier family 12 member 1; Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); solute carrier family 12, member 1; Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); urehr3
Gene Symbols SLC12A1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SLC12A1. Recombinant protein control fragment (Product #RP-91246).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6557
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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