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Invitrogen™ NKCC2 Polyclonal Antibody
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Catalog No. PIPA588905
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100 μL
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PIPA588905 100 μL
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Catalog No. PIPA588905 Supplier Invitrogen™ Supplier No. PA588905
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FGDEAQKRLR ISFRPGNQEC YDNFLQSGET AKTDASFHAY DSHTNTYYLQ TFGHNTMDAV PKIEYYRNTG SISGPKVNRP SLLEIHEQLA KNVAVTPSSA D; Positive Samples: Mouse Kidney, Rat Kidney; Cellular Location: Membrane, Multi-pass membrane protein.

The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NKCC2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.71 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene SLC12A1
Gene Accession No. P55014, P55016
Gene Alias AI788571; apical Na(2Cl)K cotransporter; BSC1; bumetanide-sensitive cotransporter type 1; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform A; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform B; bumetanide-sensitive Na-K-Cl cotransport protein splice isoform F; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; D630042G03Rik; Kidney-specific Na-K-Cl symporter; mBSC1; MGC48843; Na-K-2Cl cotransporter; NKCC2; NKCC2A variant A; SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; solute carrier family 12 member 1; Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); solute carrier family 12, member 1; Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter); urehr3
Gene Symbols SLC12A1
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20495, 25065
Target Species Mouse, Rat, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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