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NKG2D Mouse anti-Human, APC, Clone: 1D11, BD

Catalog No. BDB558071 Shop All BD Biosciences Products
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Description

Mouse Monoclonal Antibody

Antibody 1D11 reacts with NKG2D (42kDa), an activating receptor for MICA encoded within MHC. Different from natural cytotoxicity receptor (NCR), NKG2D expression is not confined to NK cells, it is also present on virtually all TCR γ/δ+ and CD8+TCR α/β+ T cells. NKG2D functions as a triggering receptor involved in natural cytotoxicity mediated by normal NK cells against a variety of tumors or normal target cells. More importantly, NKG2D can complement the role of NCR in tumor cell lysis. Remarkably, the combined maskings of NCR and NKG2D led to a complete inhibition of NK-mediated lysis of all tumor or normal cells. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: 1D11
Isotype: IgG1, κ
Cross Reactivity: Human

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen NKG2D
Applications Flow Cytometry
Classification Monoclonal
Clone 1D11
Conjugate APC
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen NKL cells
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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