NKG2D Mouse anti-Human, APC, Clone: 1D11, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 558071

Catalog No. BDB558071

Description

Antibody 1D11 reacts with NKG2D (42kDa), an activating receptor for MICA encoded within MHC. Different from natural cytotoxicity receptor (NCR), NKG2D expression is not confined to NK cells, it is also present on virtually all TCR γ/δ+ and CD8+TCR α/β+ T cells. NKG2D functions as a triggering receptor involved in natural cytotoxicity mediated by normal NK cells against a variety of tumors or normal target cells. More importantly, NKG2D can complement the role of NCR in tumor cell lysis. Remarkably, the combined maskings of NCR and NKG2D led to a complete inhibition of NK-mediated lysis of all tumor or normal cells. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: 1D11
Isotype: IgG1, κ
Cross Reactivity: Human

Flow Cytometry

Specifications

• Antigen: NKG2D
• Classification: Monoclonal
• Conjugate: APC
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 1D11
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: NKL cells
• Quantity: 100 Tests
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

For Research Use Only.