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Invitrogen™ Nkx2.6 Polyclonal Antibody
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Catalog No. FEPA5144733
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FEPA5144733 100 μL
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Catalog No. FEPA5144733 Supplier Invitrogen™ Supplier No. PA5144733
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LLSPVTSTPF SVKDILRLER ERSCPAASPH PRVRKSPENF QYLRMDAEPR GSEVHNAGGG GGDRKLDGSE Antigen sequence identity: Mouse 32%; Rat 32%.

Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas.Nkx-2.5, also designated cardiac specific homeobox protein (Csx), is a homolog of the Drosophila tinman protein and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers. Nkx-2.5 binds to DNA as a monomer, a homodimer or as a heterodimer with Nkx-2.3 or Nkx-2.6, which suggests that the specific protein-protein interactions of Nkx-2.5 are involved in its transcriptional regulatory function. Nkx-2.6, also a homolog of the Drosophila tinman protein, is expressed in the caudal pharyngeal pouches,the caudal heart progenitors, the sinus venosus, the outflow tract of the heart and in a short segment of the gut between stages E8.5 and E10.5 of embryogenesis. Expression of Nkx-2.6 overlaps with that of Nkx-2.5 in the pharynx and heart. However, Nkx-2.6 mutant mice are viable and fertile, which suggests that Nkx-2.6 plays a compensatory function to Nkx-2.5.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nkx2.6
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NKX2-6
Gene Accession No. A6NCS4
Gene Alias AV044928; CSX2; CTHM; Drosophila NK2 transcription factor related, locus 6; homeobox protein NK2 homolog F; homeobox protein NK-2 homolog F; homeobox protein NKX2.6; homeobox protein Nkx-2.6; NK2 homeobox 6; NK2 transcription factor related, locus 6; Nkx2.6; Nkx-2.6; Nkx2-6; Nkx2f; NKX4-2; tinman; tinman paralog; Tix
Gene Symbols NKX2-6
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 2-71. Recombinant protein control fragment (Product #RP-110031).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 137814
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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