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Invitrogen™ NLK Polyclonal Antibody
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Catalog No. PIPA5110834
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100 μL
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PIPA5110834 100 μL
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Catalog No. PIPA5110834 Supplier Invitrogen™ Supplier No. PA5110834
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LRGPHKQPSL PVLYTLSSQA THEAVHLLCR MLVFDPSKRI SAKDALAHPY LDEGRLRYHT CMCKCCFSTS TGRVYTSDFE PVTNPKFDDT FEKNLSSVRQ VKEIIHQFIL EQQKGNRVPL CINPQSAAFK SFISSTVAQP S Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.

NLK is a serine/threonine kinase involved in signal transduction and cellular communication. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NLK
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NLK
Gene Accession No. Q9UBE8
Gene Alias AI194375; LAK1; nemo like kinase; nemo-like kinase; NLK; Protein LAK1; RGD1561602; serine/threonine protein kinase NLK; serine/threonine-protein kinase NLK
Gene Symbols NLK
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human NLK. Recombinant protein control fragment (Product #RP-91434).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51701
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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