NLRP2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-0045	Proteintech Group Inc 151821AP150UL	150 μL

Description

NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1-b-processing activity and is thought to function as a modulator of NF-kappa-B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.

Specifications

• Antigen: NLRP2
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q9NX02
• Gene ID (Entrez): 232827, 55655
• Immunogen: NLRP2 Fusion Protein Ag7167
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: NLRP2

• Concentration: 0.21 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CLR19.9, NALP2, NBS1, NLRP2, PAN1, PYPAF2
• Gene Symbols: NLRP2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody