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NLRX1 Mouse anti-Human, Clone: OTI4H8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527207

Catalog No. PIMA527207


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Description

Description

NLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.
Specifications

Specifications

NLRX1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q86UT6
CLR11.3, DLNB26, NOD26, NOD5, NOD9, NLR family, X1, NOD-like receptor X1, caterpiller protein 11.3, nucleotide-binding oligomerization domain protein 26, nucleotide-binding oligomerization domain protein 5, nucleotide-binding oligomerization domain protein 9, nucleotide-binding oligomerization domain, leucine rich repeat containing X1
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
79671
Immunohistochemistry (Paraffin), Western Blot
OTI4H8
Unconjugated
NLRX1
Liquid
NLRX1
Human recombit protein fragment corresponding to amino acids 866-975 of NLRX1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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