NLRX1 Mouse anti-Human, Clone: OTI4H8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527207
DescriptionNLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|CLR11.3, DLNB26, NOD26, NOD5, NOD9, NLR family, X1, NOD-like receptor X1, caterpiller protein 11.3, nucleotide-binding oligomerization domain protein 26, nucleotide-binding oligomerization domain protein 5, nucleotide-binding oligomerization domain protein 9, nucleotide-binding oligomerization domain, leucine rich repeat containing X1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 866-975 of NLRX1 produced in E.coli|
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