Invitrogen™ NMDAR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ OPA104013

Catalog No. OPA104013

Description

This antibody is predicted to react with human based on 100% sequence homology. In Western blot, this antibody detects an ~100 kDa protein representing the NR1 C2 splice variant from rat brain homogenate. It shows no cross-reactivity with the NR1 N1, C1, or C2 splice variants. Reconstitute with 50 μL of PBS.

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

Specifications

• Antigen: NMDAR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRIN1
• Gene Alias: GluN1; Glun1r; GluRdelta1; Glurz1; GluRzeta1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; glutamate ionotropic receptor NMDA type subunit 1; glutamate receptor; glutamate receptor ionotropic, NMDA 1; glutamate receptor subunit zeta 1; glutamate receptor, ionotropic, NMDA1 (zeta 1); glutamate receptor, ionotropic, N-methyl D-aspartate 1; GRIN1; M100174; MRD8; neurotransmitter receptor; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDA1; Nmdar; NMDAR1; NMD-R1; NMDZ1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor 1; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMZ1; NR1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; Rgsc174; RP11-350O14.1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14810, 24408
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: 5 mM Ammonium bicarbonate with no preservative
• Gene Accession No.: P35438, P35439
• Gene Symbols: GRIN1
• Immunogen: Synthetic peptide corresponding to amino acid residues specific to the NR1 subunit of rat GRIN1, C2 splice variant insert conjugated to KLH.
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG