Invitrogen™ NMDAR2A Monoclonal Antibody (N327A/38), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545612

Catalog No. PIMA545612

Description

1 μg/mL of MA5-45612 was sufficient for detection of GluN2A/NR2A in 20 μg of COS cells transiently transfected with GFP-tagged NR2A lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 170kDa. Does not react with NR2B. This antibody was formerly sold as clone S327A-38.

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: NMDAR2A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
• Gene Accession No.: P35436, Q00959, Q12879
• Gene Symbols: Grin2a
• Immunogen: Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: N327A/38
• Conjugate: FITC
• Gene: Grin2a
• Gene Alias: EPND; FESD; GluN2A; GluRepsilon1; glutamate [NMDA] receptor subunit epsilon-1; glutamate ionotropic receptor NMDA type subunit 2A; glutamate receptor; glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, NMDA2A (epsilon 1); glutamate receptor, ionotropic, N-methyl D-aspartate 2A; Grin2a; hNR2A; LKS; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NR2A; OTTHUMP00000160135; OTTHUMP00000174531
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 14811, 24409, 2903
• Content And Storage: 4°C, store in dark
• Form: Liquid

Safety and Handling

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