Invitrogen™ NMDAR2C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595243

Catalog No. PIPA595243

Description

Human NMDAR2C shares 93% and 92.5% amino acid (aa) sequence identity with mouse and rat NMDAR2C, respectively. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Brain Tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.

Specifications

• Antigen: NMDAR2C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRIN2C
• Gene Alias: GluN2C; GluRepsilon3; glutamate [NMDA] receptor subunit epsilon-3; glutamate ionotropic receptor NMDA type subunit 2C; glutamate receptor; glutamate receptor ionotropic, NMDA 2C; glutamate receptor ionotropic, NMDA 2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, NMDA2C; glutamate receptor, ionotropic, NMDA2C (epsilon 3); glutamate receptor, ionotropic, N-methyl D-aspartate 2C; Grin2c; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C; NMDA glutamate receptor; NMDAR2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NR2; NR2C
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24411, 2905
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene Accession No.: Q00961, Q14957
• Gene Symbols: GRIN2C
• Immunogen: E.coli-derived human NMDAR2C recombinant protein (Position: Q43-Q242).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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