Invitrogen™ NMNAT3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563436

Catalog No. PIPA563436

Description

Immunogen sequence: VDPWESEQAQ WMETVKVLRH HHSKLLRSPP QMEGPDHGKA LFSTPAAVPE LKLLCGADVL KTFQTPNLWK DAHIQEIVEK FGLVCV Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.

Specifications

• Antigen: NMNAT3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NMNAT3
• Gene Alias: 4933408N02Rik; FKSG76; naMN adenylyltransferase 1; naMN adenylyltransferase 3; nicotinamide mononucleotide adenylyltransferase 3; nicotinamide nucleotide adenylyltransferase 3; Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3; nicotinamide-nucleotide adenylyltransferase 3; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 3; NMN adenylyltransferase 3; NMN/NaMN adenylyltransferase 3; NMNAT3; PNAT3; PNAT-3; pyridine nucleotide adenylyltransferase 3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 349565
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96T66
• Gene Symbols: NMNAT3
• Immunogen: Recombinant protein corresponding to Human NMNAT3. Recombinant protein control fragment (Product #RP-96415).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov