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  5. Tocris Bioscience™ NMS 873

Tocris Bioscience™ NMS 873
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Catalog No. 61805RD
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61-805-RD 5 mg
61-802-5 25 mg
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Catalog No. 61-805-RD Supplier Tocris Bioscience™ Supplier No. 6180/5
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Description

Potent and selective p97 ATPase (VCP) allosteric inhibitor

NMS 873 is a potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion.

Specifications

Chemical Name or Material 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
CAS 1418013-75-8
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C27H28N4O3S2
Formula Weight Observed MW: 520.67
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