Invitrogen™ NMT2 Monoclonal Antibody (OTI2A5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA525841

Catalog No. PIMA525841

Description

NMT2 Monoclonal Antibody for Western Blot, IHC (P)

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Specifications

• Antigen: NMT2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O60551, O70311
• Gene Symbols: NMT2
• Immunogen: Full length human recombinant protein of NMT2 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2A5
• Conjugate: Unconjugated
• Gene: NMT2
• Gene Alias: A930001K02Rik; AI605445; AU044698; fb40e03; Glycylpeptide N-tetradecanoyltransferase 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 variant 4; hNMT-2; myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; Nmt2; NMT2 protein; N-myristoyltransferase 2; peptide N-myristoyltransferase 2; Type II N-myristoyltransferase; wu:fb40e03
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18108, 291318, 9397
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid