Invitrogen™ NMT2 Polyclonal Antibody

Catalog No.	Quantity
PIPA530568	100 μL

Catalog No. PIPA530568 Supplier Invitrogen™ Supplier No. PA530568

Description

Rabbit Polyclonal Antibody

Recommended positive controls: Raji. Predicted reactivity: Mouse (96%), Rat (95%), Zebrafish (88%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Specifications

• Antigen: NMT2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.9 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene: NMT2
• Gene Accession No.: O60551
• Gene Alias: A930001K02Rik; AI605445; AU044698; fb40e03; Glycylpeptide N-tetradecanoyltransferase 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 variant 4; hNMT-2; myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; Nmt2; NMT2 protein; N-myristoyltransferase 2; peptide N-myristoyltransferase 2; Type II N-myristoyltransferase; wu:fb40e03
• Gene Symbols: NMT2
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human NMT2. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9397
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov