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Invitrogen™ NO66 Polyclonal Antibody
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Catalog No. PIPA567597
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100 μL
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PIPA567597 100 μL
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Catalog No. PIPA567597 Supplier Invitrogen™ Supplier No. PA567597
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Description

Rabbit Polyclonal Antibody

Predicted to react with Mouse and Rat samples.

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NO66
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene RIOX1
Gene Accession No. D3ZU57, Q9H6W3, Q9JJF3
Gene Alias 2410016O06Rik; 60S ribosomal protein L8 histidine hydroxylase; bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; C14orf169; chromosome 14 open reading frame 169; FLJ21802; histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; Mapjd; MNCb-7109; myc associated protein with JmjC domain; MYC-associated protein with JmjC domain; NO66; nucleolar protein 66; RGD1307704; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; RIKEN cDNA 2410016O06 gene; Riox1; ROX; similar to RIKEN cDNA 2410016O06; up-regulated in lung cancer 2; URLC2
Gene Symbols RIOX1
Host Species Rabbit
Immunogen Synthesized peptide derived from human NO66.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 314300, 71952, 79697
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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