Invitrogen™ NOC3L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536501

Catalog No. PIPA536501

Description

This antibody detects endogenous protein at a molecular weight of 93 kDa. Purity is >95% by SDS-PAGE.

GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10 or C/EBP zeta). GADD 153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and metabolic perturbations. GADD 153 functions to block cells in G1 to S phase during cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD 153 dimers away from classical C/EBP binding sites, recognizing instead unique nonclassical sites. Thus, GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells. GADD 153 belongs to the CBF/MAK21 family, which also includes NOC2L, NOC3L and NOC4L. NOC3L, also designated factor for adipocyte differentiation 24 or Fad24, promotes adipogenesis by controlling DNA replication during the early stages of mitotic clonal expansion (MCE).

Specifications

• Antigen: NOC3L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOC3L
• Gene Alias: AD24; AF233884; C10orf117; factor for adipocyte differentiation 24; Fad24; NOC3 like DNA replication regulator; NOC3 protein homolog; NOC3L; NOC3L DNA replication regulator; NOC3-like DNA replication regulator; NOC3-like protein; nucleolar complex associated 3 homolog; nucleolar complex associated 3 homolog (S. cerevisiae); nucleolar complex protein 3 homolog; Nucleolar complex-associated protein 3-like protein; RGD1560656
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361753, 57753, 64318
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8VI84, Q8WTT2
• Gene Symbols: NOC3L
• Immunogen: Synthetic peptide corresponding to amino acids 417-436 of human NOC3L.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG