Nociceptin receptor Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS0181R

Catalog No. 50-198-0120

Description

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Specifications

• Antigen: Nociceptin receptor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Oprl1
• Gene Alias: K3 opiate receptor; kappa3-related opioid receptor; Kappa-type 3 opioid receptor; KOR3; KOR-3; LC132; LC132 Receptor-Like; morc; MOR-C; N/OFQ receptor; Nociceptin receptor; nociceptin receptor ORL1; nociceptin/ orphaninFQ receptor; nociceptin/orphanin FQ receptor; NOCIR; NOP; NOPr; OFQR; Oor; opiate receptor-like 1; opioid receptor-like 1; opioid receptor-like protein Zf-orl; opioid related nociceptin receptor 1; opioid-receptor-like protein; OPPRL1; Oprl; OPRL1; ORGC; ORL1; Orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR; XOR1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4987
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P41146
• Gene Symbols: Oprl1
• Immunogen: KLH conjugated synthetic peptide derived from mouse Nociceptin receptor .
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG