Invitrogen™ NOD1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518027

Catalog No. PIPA518027

Description

This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.

Specifications

• Antigen: NOD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOD1
• Gene Alias: C230079P11; Card4; caspase recruitment domain 4; caspase recruitment domain family, member 4; caspase recruitment domain-containing protein 4; CLR7.1; F830007N14Rik; NLR family, CARD domain containing 1; Nlrc1; Nod1; nucleotide binding oligomerization domain containing 1; nucleotide-binding oligomerization domain containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; nucleotide-binding oligomerization domain-containing protein 1; RGD1562269
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 10392
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9Y239
• Gene Symbols: NOD1
• Immunogen: Synthetic peptide sequence (EAKVYEDEKRIICF) corresponding to the C-terminus amino acids of NOD1 (aa 940-953).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG