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Invitrogen™ NOD3 Polyclonal Antibody
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Catalog No. PIPA5115658
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PIPA5115658 100 μL
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Catalog No. PIPA5115658 Supplier Invitrogen™ Supplier No. PA5115658
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NLRC3.

NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOD3
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene NLRC3
Gene Accession No. Q5DU56, Q7RTR2
Gene Alias CARD15-like protein; caterpillar 16.2; Caterpiller 16.2; caterpiller protein 16.2; CLR16.2; D230007K08Rik; mFLJ00348; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain containing 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NLR family, CARD domain containing 3, pseudogene 1; Nlrc3; Nlrc3-ps1; NOD3; NOD-like receptor C3; Nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; protein NLRC3; RGD1304902
Gene Symbols NLRC3
Host Species Rabbit
Immunogen A synthesized peptide derived from human NLRC3(Accession Q7RTR2), corresponding to amino acid residues L1026-M1065.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 197358, 268857, 287070
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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