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Invitrogen™ Nodal Polyclonal Antibody
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Catalog No. PIPA523084
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50 μL
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PIPA523084 50 μL
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Catalog No. PIPA523084 Supplier Invitrogen™ Supplier No. PA523084
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Description

Rabbit Polyclonal Antibody

The target sequence has 98% sequence homology with rat.

NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nodal
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.32 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide
Gene NODAL
Gene Accession No. P43021, Q96S42
Gene Alias early embryo mesoderm formation; HTX5; MGC138230; Nodal; nodal growth differentiation factor; nodal homolog; Tg.413d; transgenic lethal 413.d
Gene Symbols NODAL
Host Species Rabbit
Immunogen A genomic peptide made to a C-terminal region of the human NODAL protein (within residues 200-347).
Purification Method Antigen affinity chromatography
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18119, 4838
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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