Invitrogen™ Nofetumomab Recombinant Mouse Monoclonal Antibody

Mouse Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA541755

Catalog No. PIMA541755

Description

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Technetium Tc-99m nofetumomab merpentan (Tc-99m nm) consists of a Fab fragment of an IgG2b of the pancarcinoma murine antibody NR-LU-10. 1The NR-LU-10 antibody is directed against a 40 kDa glycoprotein antigen expressed in a variety of cancers and some normal tissues. LabelTc-99m nm was developed by Boehringer Ingelheim Pharma KG and FDA approved on September 14, 1992. It was after discontinued on August 13, 2013, but in the 2018 FDA submission list, it can be found as a substance type II (pharmaceutical substance) with an active status. The mechanism of action in Tc-99m nm is ruled by the presence of nofetumomab, which can recognize the pancarcinoma antigen EpCAM and/or CD20/MS4A1, 2and merpentan, that acts as a linker for the binding of technetium.

Specifications

• Antigen: Nofetumomab
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene Alias: Verluma; Technetium (99mTc) nofetumomab merpentan
• Immunogen: Human CD20/MS4A1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical

• Applications: ELISA, SDS-Page
• Concentration: 2.2 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ