Invitrogen™ Noggin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534595

Catalog No. PIPA534595

Description

Not suitable for use with Immunohistochemistry - Free Floating. This antibody is predicted to react with horse, chicken and Xenopus laevis based on sequence homology.

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

Specifications

• Antigen: Noggin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOG
• Gene Alias: NOG; Noggin; Noggin precursor; noggin; LOW QUALITY PROTEIN: noggin; SYM1; symphalangism 1 (proximal); SYNS1; SYNS1A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18121, 9241
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.9 mg/mL
• Formulation: PBS with 0.02% sodium azide; pH 7.4
• Gene Accession No.: P97466, Q13253
• Gene Symbols: NOG
• Immunogen: Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Noggin.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG