Invitrogen™ NOLA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599801

Catalog No. PIPA599801

Description

Antibody detects endogenous levels of total NOLA1.

Required for ribosome biogenesis and telomere maintenance. NOLA1 is part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. NOLA1 may also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Specifications

• Antigen: NOLA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GAR1
• Gene Alias: AA409823; AI326794; C430047J18Rik; Gar1; GAR1 homolog, ribonucleoprotein; GAR1 ribonucleoprotein; GAR1 ribonucleoprotein homolog; GAR1 ribonucleoprotein homolog (yeast); H/ACA ribonucleoprotein complex subunit 1; H/ACA small nucleolar RNPs; Nola1; Nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs); snoRNP protein GAR1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 499709, 54433, 68147
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6AYA1, Q9CY66, Q9NY12
• Gene Symbols: GAR1
• Immunogen: A synthesized peptide derived from human GAR1(Accession Q9NY12), corresponding to amino acid residues A135-R185.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG