Invitrogen™ NOLA1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5143962	100 μg

Catalog No. PIPA5143962 Supplier Invitrogen™ Supplier No. PA5143962

Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human A375 whole cell, human K562 whole cell, human HL-60 whole cell, human MCF-7 whole cell. IHC: human breast cancer tissue, human gastric carcinoma tissue, human liver cancer tissue, human ovarian adenoma tissue, human pancreatic cancer tissue, human prostate cancer tissue, human glioma tissue, human lymphoma tissue. ICC/IF: MCF-7 cell. Flow: K562 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Required for ribosome biogenesis and telomere maintenance. NOLA1 is part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. NOLA1 may also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Specifications

• Antigen: NOLA1
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: GAR1
• Gene Accession No.: Q9NY12
• Gene Alias: AA409823; AI326794; C430047J18Rik; Gar1; GAR1 homolog, ribonucleoprotein; GAR1 ribonucleoprotein; GAR1 ribonucleoprotein homolog; GAR1 ribonucleoprotein homolog (yeast); H/ACA ribonucleoprotein complex subunit 1; H/ACA small nucleolar RNPs; Nola1; Nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs); snoRNP protein GAR1
• Gene Symbols: GAR1
• Host Species: Rabbit
• Immunogen: E.coli-derived human NOLA1/GAR1 recombinant protein (Position: F58-K165).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 54433
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG