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Invitrogen™ Nop25 Polyclonal Antibody
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Catalog No. PIPA5103984
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100 μL
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PIPA5103984 100 μL
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Catalog No. PIPA5103984 Supplier Invitrogen™ Supplier No. PA5103984
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NOL12.

Nop25 is a nucleolar protein predominantly involved in the architecture and function of the nucleolus, which is the cellular hub for ribosomal RNA (rRNA) synthesis and ribosome assembly. It is identified as a putative RNA-binding protein and plays a crucial role in rRNA transcription. Nop25 has been characterized through molecular cloning, showing its ability to bind single-stranded nucleic acids directly. Experimental studies, such as those involving mouse embryogenesis, have utilized techniques like RT-PCR to analyze Nop25's gene expression across developmental stages. Moreover, research on the protein's structure has unveiled its nuclear and nucleolar targeting sequences, vital for its localization to the nucleolus. Treatment of cells with RNase A has illustrated the dissociation of Nop25 from the nucleolus, further highlighting its RNA-binding capabilities. This protein's functional importance is underscored by its role in maintaining nucleolar architecture, as demonstrated by experiments where overexpression of Nop25's N-terminal amino acids disrupted nucleolar integrity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nop25
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene NOL12
Gene Accession No. Q5D1Z3, Q8BG17, Q9UGY1
Gene Alias 25 kDa nucleolar protein; C78541; dJ37E16.7; Nol12; Nop25; Nucleolar protein 12; nucleolar protein of 25 kDa; nucleolar protein, 25 kDa; RGD1305327
Gene Symbols NOL12
Host Species Rabbit
Immunogen A synthesized peptide derived from human NOL12(Accession Q9UGY1), corresponding to amino acid residues S162-G212.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362955, 79159, 97961
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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