Invitrogen™ NOP56 Monoclonal Antibody (CL2603)

Catalog No.	Quantity
PIMA524641	100 μL

Catalog No. PIMA524641 Supplier Invitrogen™ Supplier No. MA524641

Description

Mouse Monoclonal Antibody

Immunogen sequence: EDPSISFSKP KKKKSFSKEE LMSSDLEETA GSTS Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 62%. Binds to an epitope located within the peptide sequence FSKEELMSSDLEETA as determined by overlapping synthetic peptides.

ErbB 4 (Her-4, c-erbB-4, v-erbB-4) is a member of the class I receptor kinase family. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.

Specifications

• Antigen: NOP56
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: CL2603
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Nop56
• Gene Accession No.: O00567
• Gene Alias: 2310044F10Rik; 56kDa with KKE/D repeat; hypothetical protein 1195; NOL5A; Nop56; NOP56 ribonucleoprotein; NOP56 ribonucleoprotein homolog; nucleolar protein 56; Nucleolar protein 5A; nucleolar protein 5A (56kDa with KKE/D repeat); SCA36; similar to nucleolar protein 5A (56kDa with KKE/D repeat)
• Gene Symbols: Nop56
• Host Species: Mouse
• Immunogen: Recombinant protein fragment of Human NOP56 (Product #RP-100887)
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10528
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1