Invitrogen™ Norepinephrine Transporter Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA542080

Catalog No. PIPA542080

Description

Peptide sequence: FTPAAEFYER GVLHLHESSG IHDIGLPQWQ LLLCLMVVVI VLYFSLWKGV Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

Norepinephrine Transporter [NET, or noradrenaline transporter (NAT)] is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression. Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD.

Specifications

• Antigen: Norepinephrine Transporter
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC6A2
• Gene Alias: NaCl-dependent norepinephrine transporter; NAT1; NE transporter; NET; NE-T; NET1; neurotransmitter transporter; neurotransmitter transporter, noradrenal; NORADR; noradrenaline; noradrenaline transporter; norepinephrine transporter; Slc6a2; SLC6A5; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; solute carrier family 6 member 2; solute carrier family 6 member 5; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6530, 83511
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P23975
• Gene Symbols: SLC6A2
• Immunogen: Synthetic peptide directed towards the middle region of human SLC6A2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov