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Invitrogen™ NOSIP Polyclonal Antibody
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Catalog No. PIPA530613
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100 μL
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PIPA530613 100 μL
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Catalog No. PIPA530613 Supplier Invitrogen™ Supplier No. PA530613
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Raji, mouse brain. Predicted reactivity: Mouse (89%), Rat (90%), Rhesus Monkey (99%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1. 2, Nav1. 3, Nav1. 5, Nav1. 7, Nav1. 8, Kv1. 3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOSIP
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.53 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene NOSIP
Gene Accession No. Q9D6T0, Q9Y314
Gene Alias 2310061K06Rik; CGI-25; E3 ubiquitin-protein ligase NOSIP; eNOS-interacting protein; nitric oxide synthase interacting protein; nitric oxide synthase-interacting protein; Nosip; RING-type E3 ubiquitin transferase NOSIP
Gene Symbols NOSIP
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human NOSIP. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51070, 66394
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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