NOTCH 1Rabbit anti-Human, Polyclonal, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 100401405

Catalog No. 50-199-0068

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Notch1 antibody is directed against human NOTCH 1. No reaction is detected against NOTCH 2. No reactivity was observed against Mouse Notch. Other species have not been tested.

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

Specifications

• Antigen: NOTCH 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Notch1
• Gene Alias: 9930111A19Rik; AOS5; AOVD1; BOS_12152; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; Neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; Notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; NOTCH1; p300; RP23-306D20.12; RP23-306D20.12-001; TAN1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
• Host Species: Rabbit
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Concentration: 75 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Accession No.: P46531
• Gene Symbols: Notch1
• Immunogen: Anti-Notch antibody was prepared by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acid 2480-2510 of human Notch 1. A residue of cysteine was added to the amino terminal end to facilitate coupling.
• Regulatory Status: RUO
• Gene ID (Entrez): 4851
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid