Notch1 Monoclonal Antibody (ICN 5B5), Active Motif™

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3185	Active Motif 61148	10 μg
50-199-3184	Active Motif 61147	100 μg

Description

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

Specifications

• Antigen: Notch1
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Alias: 9930111A19Rik; AOS5; AOVD1; BOS_12152; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; Neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; Notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; NOTCH1; p300; RP23-306D20.12; RP23-306D20.12-001; TAN1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
• Gene Symbols: Notch1
• Isotype: IgG2b
• Purification Method: Protein G
• Product Type: Antibody

• Clone: ICN 5B5
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rat
• Target Species: Human, Rat
• Gene Accession No.: P46531, Q07008
• Gene ID (Entrez): 25496, 4851
• Immunogen: This Notch1 antibody was raised against a recombinant protein corresponding to the intracellular domain of human Notch1.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: Notch1