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Invitrogen™ NOTCH2 Chimeric Recombinant Rabbit Monoclonal Antibody (B9)
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Catalog No. PIMA547822
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200 μg
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Catalog No. Quantity
PIMA547822 200 μg
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Catalog No. PIMA547822 Supplier Invitrogen™ Supplier No. MA547822
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2 but not NRR1.

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH2 Chimeric
Applications ELISA, Inhibition Assays, Immunocytochemistry
Classification Recombinant Monoclonal
Clone B9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene NOTCH2
Gene Accession No. O35516, Q04721
Gene Alias AGS2; AI853703; HJCYS; hN2; Motch B; N2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; notch gene homolog 2; Notch homolog 2; notch receptor 2; Notch2
Gene Symbols NOTCH2
Host Species Rabbit
Immunogen NRR of mouse Notch 2.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18129, 4853
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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