Invitrogen™ NOTCH2 Monoclonal Antibody (605724)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA524274

Catalog No. PIMA524274

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

Specifications

• Antigen: NOTCH2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O35516
• Gene Symbols: NOTCH2
• Immunogen: CHO-derived recombinant mouse Notch-2 Leu26-Val528 (predicted).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry
• Clone: 605724
• Conjugate: Unconjugated
• Gene: NOTCH2
• Gene Alias: AGS2; AI853703; HJCYS; hN2; Motch B; N2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; notch gene homolog 2; Notch homolog 2; notch receptor 2; Notch2
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 18129
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized