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Invitrogen™ NOTCH2 Polyclonal Antibody
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Catalog No. PIPA523455
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100 μg
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Catalog No. Quantity
PIPA523455 100 μg
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Catalog No. PIPA523455 Supplier Invitrogen™ Supplier No. PA523455
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Description

Rabbit Polyclonal Antibody

Sequence homology: Mouse, Rat, Canine, Bovine (88%).

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene NOTCH2
Gene Accession No. Q04721
Gene Alias AGS2; AI853703; HJCYS; hN2; Motch B; N2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; notch gene homolog 2; Notch homolog 2; notch receptor 2; Notch2
Gene Symbols NOTCH2
Host Species Rabbit
Immunogen A portion of amino acids 1550-1600 of humanNOTCH2.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4853
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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