Invitrogen™ NOTCH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587455

Catalog No. PIPA587455

Description

Immunogen sequence: SRLHPVPVPA DWMNRMEVNE TQYNEMFGMV LAPAEGTHPG IAPQSRPPEG KHITTPREPL PPIVTFQLIP KGSIAQPAGA PQPQSTCPPA VAGPLPTMYQ IPEMARLPSV AFPTAMMPQQ DGQVAQTILP AYHPFPASVG KYPTPPSQHS YASSNAAERT PSHSGHLQGE HPYLTPSPES PDQWSSSSPH SASDWSDVTT SPTPGGAGGG QRGPGTHMSE PPHNNMQVYA; Positive Samples: 293T, LO2, HeLa; Cellular Location: Cell membrane, Cytoplasm, Nucleus, Single-pass type I membrane protein.

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

Specifications

• Antigen: NOTCH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOTCH2
• Gene Alias: AGS2; AI853703; HJCYS; hN2; Motch B; N2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; notch gene homolog 2; Notch homolog 2; notch receptor 2; Notch2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18129, 4853
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O35516, Q04721
• Gene Symbols: NOTCH2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2242-2471 of human NOTCH2 (NP_0777192).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG