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Invitrogen™ NOTCH2 (Cleaved Ala1734) Polyclonal Antibody
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Catalog No. PIPA599429
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100 μL
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PIPA599429 100 μL
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Catalog No. PIPA599429 Supplier Invitrogen™ Supplier No. PA599429
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of fragment of activated Notch2 resulting from cleavage adjacent to Ala1734.

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH2 (Cleaved Ala1734)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene NOTCH2
Gene Accession No. O35516, Q04721, Q9QW30
Gene Alias AGS2; AI853703; HJCYS; hN2; Motch B; N2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; notch gene homolog 2; Notch homolog 2; notch receptor 2; Notch2
Gene Symbols NOTCH2
Host Species Rabbit
Immunogen A synthesized peptide derived from human NOTCH2(Accession Q04721), corresponding to amino acid residues N1723-T1752.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18129, 29492, 4853
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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